Stan Wawrinka made his 21st and final Roland-Garros appearance, losing in the first round to Jesper de Jong on 25 May.
Tournament organisers held an on-court tribute for Wawrinka, including a video and messages from Federer, Nadal and Djokovic.
Gaël Monfils also made his farewell French Open appearance, losing in the first round to Hugo Gaston before his own tribute.
On 21 May, Monfils headlined a 'Gael and Friends' exhibition at Court Philippe-Chatrier with Sinner, Djokovic, Osaka and others.
Proceeds from the exhibition were donated to charitable organisations including the FFT's Terre d'Impact foundation.